AFRO-AMERICAN MUSIC INSTITUTE CELEBRATES 36 YEARS
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Pain Relief Beyond Belief
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From Blakey to Brown, Como to Costa, Eckstine to Eldridge, Galbraith to Garner, Harris to Hines, Horne to Hyman, Jamal to Jefferson, Kelly to Klook; Mancini to Marmarosa, May to Mitchell, Negri to Nestico, Parlan to Ponder, Reed to Ruther, Strayhorn to Sullivan, Turk to Turrentine, Wade to Williams… the forthcoming publication Treasury of Pittsburgh Jazz Connections by Dr. Nelson Harrison and Dr. Ralph Proctor, Jr. will document the legacy of one of the world’s greatest jazz capitals.
Do you want to know who Dizzy Gillespie idolized? Did you ever wonder who inspired Kenny Clarke and Art Blakey? Who was the pianist that mentored Monk, Bud Powell, Tad Dameron, Elmo Hope, Sarah Vaughan and Mel Torme? Who was Art Tatum’s idol and Nat Cole’s mentor? What musical quartet pioneered the concept adopted later by the Modern Jazz Quartet? Were you ever curious to know who taught saxophone to Stanley Turrentine or who taught piano to Ahmad Jamal? What community music school trained Robert McFerrin, Sr. for his history-making debut with the Metropolitan Opera? What virtually unknown pianist was a significant influence on young John Coltrane, Shirley Scott, McCoy Tyner, Bobby Timmons and Ray Bryant when he moved to Philadelphia from Pittsburgh in the 1940s? Would you be surprised to know that Erroll Garner attended classes at the Julliard School of Music in New York and was at the top of his class in writing and arranging proficiency?
Some answers can be gleaned from the postings on the Pittsburgh Jazz Network.
For almost 100 years the Pittsburgh region has been a metacenter of jazz originality that is second to no other in the history of jazz. One of the best kept secrets in jazz folklore, the Pittsburgh Jazz Legacy has heretofore remained mythical. We have dubbed it “the greatest story never told” since it has not been represented in writing before now in such a way as to be accessible to anyone seeking to know more about it. When it was happening, little did we know how priceless the memories would become when the times were gone.
Today jazz is still king in Pittsburgh, with events, performances and activities happening all the time. The Pittsburgh Jazz Network is dedicated to celebrating and showcasing the places, artists and fans that carry on the legacy of Pittsburgh's jazz heritage.
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MARY LOU WILLIAMS
¿Busca un apicoplast pdf online? FilesLib está aquí para ayudarle a ahorrar tiempo en la búsqueda. Los resultados de la búsqueda incluyen el nombre del manual, la descripción, el tamaño y el número de páginas. Puede leer el apicoplast pdf online o descargarlo en su ordenador.
apicoplast-specific mechanism. Inhibition of apicoplast biogenesis in the second intraerythrocytic cycle is a hallmark of 1-3 µM DOX-treated P. falciparum, resulting in unviable parasite progeny that fail to inherit the organelle (2). IPP rescues parasite viability after the second cycle without rescuing apicoplast Since humans and animals have no plastids, the apicoplast is an attractive target for drug development. Indeed, after its discovery, the apicoplast was found to host the target pathways of some known antimalarial drugs, which motivated efforts for further research into its biological functions and biogenesis. Apicoplast, An apicoplast is a derived non- photosynthetic plastid found in most Apicomplexa, including Toxoplasma gondii, and Plasmodium falciparum and other Plasmodium spp. (parasites causing malaria), but not in others such as Cryptosporidium. the apicoplast is a vestigial nonphotosynthetic plastid, surrounded by four membranes due to its secondary, endosymbiosis origin. Indeed, an ancient eukaryotic, cell engulfed a cyanobacterium to become a photosyn-, thetic eukaryotic alga. Then, a Plasmodium predecessor, ingested the eukaryotic alga to establish a new symbio-, El apicoplasto es un orgánulo presente en la célula de la mayoría de los protistas llamados Apicomplexa (en español Apicomplejos), incluyendo Plasmodium, pero ausente en otras especies como Cryptosporidium. 1 2 Cada célula contiene un único apicoplasto y son homólogos a los cloroplastos de los dinoflagelados, pero han perdido la clorofila y The apicoplast is a distinctive organelle associated, with apicomplexan parasites, includingPlasmodiumsp. (which cause malaria) andToxoplasma gondii(the caus-, ative agent of toxoplasmosis). This unusual structure, (acquired by the engulfment of an ancestral alga and, retention of the algal plastid) is essential for long-term, parasite survival. binding site in apicoplast LSU rRNA, reduced P. falci-parum apicoplast EF-Tu levels thus strengthening the view that translation in the apicoplast is the site of action of this drug. Introduction Apicomplexan parasites, including Plasmodium and Tox-oplasma, possess a plastid-like organelle called the api-coplast (Wilson et al., 1996; Kohler et al The apicoplast, a chloroplast-like organelle of the , Plasmodiumparasite has been shown to be essential for the parasite survival and offers a new drug target to exploit. How the parasite distributes this essential organelle during the asexual replication has been an open question up to this point. C. Tomova and others Figure 2 Structure of the apicoplast and variation in size and shape of the protuberances (A-D) Representative tomographic slices, of a thickness of approx. 6 nm, of the three-dimensional double-tilt reconstruction offour different apicoplasts. The images elucidate most of the features of the apicoplast revealed by tomography: firstly, the four The apicoplast is a relic, non-photosynthetic, plastid-like, organelle derived from secondary endosymbiosis (6,7). The apicoplast harbours key metabolic pathways such as, the fatty acid synthesis type II (FAS II), the isoprenoid, and the haem synthesis (8-11) that are essential for, the viability and survival of the parasite (12,13). The, Apicoplast-targeted genes in general ar
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