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Elevated Plus Maze Take caution not to move the maze, as the tracking software has been precisely calibrated according to its position. See manual (Biobserve Viewer Manual.pdf) for further information. Figure 1: Transfer to .xls. Setup: 1) Switch on computer. 2) Open Viewer II. 3) Check that the "Current Configuration" displayed in the top right corner of the screen is EPM_final.vcd. If The elevated plus maze test is used to measure anxiety-like behavior in rodents. It can be used to gain insight into conditions such as posttraumatic stress disorder (PTSD) and other conditions marked by anxious behavior. It can also be used as a component in screening of novel compounds for anxiolytic properties. elevated plus maze specifications San Diego Instruments, Inc. 9155 Brown Deer Rd, Suite 8 San Diego, CA 92121 Ph: 858-530-2600 Fax: 858-530-2646 sandiegoinstruments.com product name part numbers Plus Maze for Mice Black 7001-0225 White 7001-0336 Beige 7001-0316 Plus Maze for Rats Black 7001-0227 White 7001-0338 Beige 7001-0337 Anxiety, defence and the elevated plus-maze. The elevated plus-maze test has been in use as a rodent model of anxiety for a decade, and is representative of those tests that are based upon the study of spontaneous behaviour patterns and which ave high ecological validity. The origins of the test in studies of the relationship between The elevated plus maze has been described as a simple method for assessing anxiety responses of rodents by File and co-workers 1. A task, using a Y-shaped apparatus that included an elevated open 6.2.4. The Elevated Plus Maze Unless otherwise stated all mice were male, naïve to the Elevated Plus Maze apparatus and from the congenic strain. Unaffected and MPS IIIA mice were 7-, 15-, 18- or 20-wks of age when tested and the group sizes for each of the Elevated Plus Maze trials are summarised in Table 6.1. These mice had not undergone The elevated plus-maze (EPM) test is one of the most commonly used behavioral assays to evaluate anxiety-related behavior in rodents. It is an economic test (5 min duration) without prior conditioning of the animals. The critical measure for anxiety is the time spent in the open arms of the maze. A confounding problem of the EPM is the so Description of procedure: The Elevated Plus Maze (EPM) is used to assess anxiety, emotionality and reactivity. The Plus Maze consists of two enclosed arms and two open arms equipped with rows of infrared photocells interfaced with a computer. While the open arms are, by design, anxiogenic, the animal is free to move into the closed arms. Elevated plus maze, a well known model is utilized for the assessment of anxiety-like behaviour in rodents in which elevated and open place entry is avoided [23, 24]. Different antidepressant drugs including TCA, NMDA receptor antagonists or SSRIs enhance the occurrence of escape-related behavior and overtune the immobility position. It is concluded that during a brief (5 min) trial in the plus-maze rats acquire a specific phobic anxiety, which is relatively resistant to benzodiazepines, which with a longer exposure to thePlus-Maze this form of fear extinguishes. A factor analysis of the